St Helens| 4 | | Odsal | | > | | Sat | 12 Feb 1949 | Castleford | 10 | Bramley | 2 | | Wheldon Road | | > |
| Sat | 12 Feb 1949 | Dewsbury | 9 | Barrow | 6 | | Crown Flatt | | > |
| Sat | 12 Feb 1949 | Huddersfield | 4 | Rochdale H. | 5 | | Fartown | | > |
| Sat | 12 Feb 1949 | Hull | 4 | Halifax | 0 | | Boulevard | | > |
| Sat | 12 Feb 1949 | Hunslet | 22 | Salford | 0 | | Parkside | | > |
| Sat | 12 Feb 1949 | Leeds | 16 | Batley | 2 | | Headingley | | > |
| Sat | 12 Feb 1949 | Liverpool S. | 3 | Wakefield T. | 32 | | Stanley | | > |
| Sat | 12 Feb 1949 | Normanton | 4 | Belle Vue R. | 9 | | Belle Vue | | > |
| Sat | 12 Feb 1949 | Oldham | 30 | Broughton Moor | 0 | | Watersheddings | | > |
| Sat | 12 Feb 1949 | Swinton | 15 | Featherstone R. | 2 | | Station Road | | > |
| Sat | 12 Feb 1949 | Vine Tavern | 4 | York | 11 | | Knowsley | | > |
| Sat | 12 Feb 1949 | Warrington | 17 | Hull KR | 7 | | Wilderspool | | > |
| Sat | 12 Feb 1949 | Whitehaven | 0 | Keighley | 0 | | Recreation Gnd | | > |
| Sat | 12 Feb 1949 | Wigan | 11 | Leigh | 12 | | Central Park | | > |
| Sat | 12 Feb 1949 | Workington | 6 | Widnes | 7 | | Borough Park | | > |
| Challenge Cup - Rd. 1 (2nd Leg)
|
|---|
| Sat | 19 Feb 1949 | Barrow | 13 | Dewsbury | 9 | | Craven Park | | > |
| Sat | 19 Feb 1949 | Batley | 4 | Leeds | 7 | | Mount Pleasant | | > |
| Sat | 19 Feb 1949 | Belle Vue R. | 12 | Normanton | 0 | | Belle Vue | | > |
| Sat | 19 Feb 1949 | Bramley | 2 | Castleford | 10 | | Barley Mow | | > |
| Sat | 19 Feb 1949 | Broughton Moor | 2 | Oldham | 35 | | Borough Park | | > |
| Sat | 19 Feb 1949 | Featherstone R. | 13 | Swinton | 10 | | Post Office Road | | > |
| Sat | 19 Feb 1949 | Halifax | 10 | Hull | 0 | | Thrum | | > |
| Sat | 19 Feb 1949 | Hull KR | 5 | Warrington | 28 | | Craven Park | | > |
| Sat | 19 Feb 1949 | Keighley | 19 | Whitehaven | 9 | | Lawkholme Lane | | > |
| Sat | 19 Feb 1949 | Leigh | 4 | Wigan | 5 | | Kirkhall | | > |
| Sat | 19 Feb 1949 | Rochdale H. | 0 | Huddersfield | 11 | | Athletic Ground | | > |
| Sat | 19 Feb 1949 | St Helens | 0 | Bradford N. | 5 | | Knowsley | | > |
| Sat | 19 Feb 1949 | Salford | 11 | Hunslet | 10 | | The Willows | | > |
| Sat | 19 Feb 1949 | Wakefield T. | 41 | Liverpool S. | 12 | | Belle Vue | | > |
| Sat | 19 Feb 1949 | Widnes | 0 | Workington | 10 | | Naughton | | > |
| Sat | 19 Feb 1949 | York | 17 | Vine Tavern | 3 | | Wigginton Rd | | > |
| Challenge Cup - Round 1 (Rep)
|
|---|
| Sat | 26 Feb 1949 | Leigh | 4 | Wigan | 10 | | Kirkhall | | > |
| Challenge Cup - Round 2
|
|---|
| Sat | 05 Mar 1949 | Barrow | 13 | Keighley | 2 | | Craven Park | | > |
| Sat | 05 Mar 1949 | Belle Vue R. | 8 | Warrington | 3 | | Belle Vue | | > |
| Sat | 05 Mar 1949 | Bradford N. | 11 | Castleford | 5 | | Odsal | | > |
| Sat | 05 Mar 1949 | Halifax | 5 | Swinton | 0 | | Thrum | | > |
| Sat | 05 Mar 1949 | Huddersfield | 3 | Workington | 0 | | Fartown | | > |
| Sat | 05 Mar 1949 | Leeds | 14 | Hunslet | 8 | | Headingley | | > |
| Sat | 05 Mar 1949 | York | 3 | Oldham | 4 | | Wigginton Rd | | > |
| Wed | 09 Mar 1949 | Wigan | 37 | Wakefield T. | 2 | | Central Park | | > |
| Challenge Cup - Round 3
|
|---|
| Sat | 19 Mar 1949 | Barrow | 8 | Wigan | 7 | | Craven Park | | > |
| Sat | 19 Mar 1949 | Bradford N. | 8 | Belle Vue R. | 7 | | Odsal | | > |
| Sat | 19 Mar 1949 | Leeds | 9 | Huddersfield | 20 | | Headingley | | > |
| Sat | 19 Mar 1949 | Oldham | 2 | Halifax | 7 | | Watersheddings | | > |
| Challenge Cup - Semi Final
|
|---|
| Sat | 02 Apr 1949 | Bradford N. | 10 | Barrow | 0 | | Station Road | 26,900 | > |
| Sat | 02 Apr 1949 | Halifax | 11 | Huddersfield | 10 | | Odsal | 64,250 | > |
| Challenge Cup - Final
|
|---|
| Sat | 07 May 1949 | Bradford N. | 12 | Halifax | 0 | | Wembley | 95,050 | > |