Bradford N.| 7 | | Sandy Lane | | > | | Sat | 26 Feb 1921 | Dewsbury | 12 | Hull KR | 0 | | Crown Flatt | | > |
| Sat | 26 Feb 1921 | Featherstone R. | 41 | Pendlebury | 0 | | Post Office Road | | > |
| Sat | 26 Feb 1921 | Halifax | 5 | Batley | 0 | | Thrum | | > |
| Sat | 26 Feb 1921 | Hull | 5 | Warrington | 5 | | Boulevard | | > |
| Sat | 26 Feb 1921 | Hunslet | 7 | Leeds | 8 | | Parkside | | > |
| Sat | 26 Feb 1921 | Keighley | 5 | Rochdale H. | 10 | | Lawkholme Lane | | > |
| Sat | 26 Feb 1921 | Leigh | 0 | York | 0 | | Mather Lane | | > |
| Sat | 26 Feb 1921 | Oldham | 41 | Elland Wanderers | 5 | | Watersheddings | | > |
| Sat | 26 Feb 1921 | St Helens Recs | 9 | Wigan | 6 | | City Road | 26,000 | > |
| Sat | 26 Feb 1921 | St Helens | 0 | Bramley | 7 | | Knowsley | | > |
| Sat | 26 Feb 1921 | Salford | 4 | Barrow | 0 | | Weaste | | > |
| Sat | 26 Feb 1921 | Swinton | 25 | BOCM | 5 | | Chorley Road | | > |
| Sat | 26 Feb 1921 | Wakefield T. | 4 | Huddersfield | 8 | | Belle Vue | | > |
| Sat | 26 Feb 1921 | Widnes | 41 | Dearham | 5 | | Lowerhouse | | > |
| Sat | 26 Feb 1921 | Wigan H. | 10 | Broughton R. | 15 | | Tunstall Lane | | > |
| Wed | 02 Mar 1921 | Warrington | 16 | Hull | 5 | | Wilderspool | | > |
| Wed | 02 Mar 1921 | York | 0 | Leigh | 3 | | Wigginton Rd | | > |
| Challenge Cup - Round 2
|
|---|
| Sat | 12 Mar 1921 | Bradford N. | 7 | Swinton | 3 | | Birch Lane | | > |
| Sat | 12 Mar 1921 | Bramley | 4 | Halifax | 13 | | Barley Mow | | > |
| Sat | 12 Mar 1921 | Broughton R. | 3 | Rochdale H. | 5 | | The Cliff | | > |
| Sat | 12 Mar 1921 | Featherstone R. | 0 | Dewsbury | 22 | | Post Office Road | | > |
| Sat | 12 Mar 1921 | Huddersfield | 8 | Oldham | 3 | | Fartown | | > |
| Sat | 12 Mar 1921 | Leigh | 10 | Warrington | 10 | | Mather Lane | | > |
| Sat | 12 Mar 1921 | St Helens Recs | 0 | Widnes | 7 | | City Road | 20,000 | > |
| Sat | 12 Mar 1921 | Salford | 0 | Leeds | 21 | | Weaste | | > |
| Wed | 16 Mar 1921 | Warrington | 3 | Leigh | 8 | | Wilderspool | | > |
| Challenge Cup - Round 3
|
|---|
| Sat | 02 Apr 1921 | Dewsbury | 0 | Rochdale H. | 0 | | Crown Flatt | | > |
| Sat | 02 Apr 1921 | Halifax | 5 | Widnes | 2 | | Thrum | | > |
| Sat | 02 Apr 1921 | Huddersfield | 5 | Leeds | 3 | | Fartown | | > |
| Sat | 02 Apr 1921 | Leigh | 7 | Bradford N. | 0 | | Mather Lane | | > |
| Tue | 05 Apr 1921 | Rochdale H. | 5 | Dewsbury | 2 | | Athletic Ground | | > |
| Challenge Cup - Semi Final
|
|---|
| Sat | 16 Apr 1921 | Halifax | 2 | Huddersfield | 0 | | Headingley | 23,500 | > |
| Sat | 16 Apr 1921 | Leigh | 10 | Rochdale H. | 0 | | Central Park | 20,000 | > |
| Challenge Cup - Final
|
|---|
| Sat | 30 Apr 1921 | Leigh | 13 | Halifax | 0 | | Wheater's | 25,000 | > |