Featherstone R.| 8 | | Craven Park | | > | | Sat | 07 Feb 1953 | Batley | 6 | Bradford N. | 15 | | Mount Pleasant | | > |
| Sat | 07 Feb 1953 | Belle Vue R. | 10 | Keighley | 2 | | Belle Vue | | > |
| Sat | 07 Feb 1953 | Halifax | 14 | Dewsbury | 7 | | Thrum | | > |
| Sat | 07 Feb 1953 | Huddersfield | 36 | Castleford | 14 | | Fartown | | > |
| Sat | 07 Feb 1953 | Hull KR | 12 | Doncaster | 0 | | Craven Park | | > |
| Sat | 07 Feb 1953 | Hunslet | 14 | Workington | 12 | | Parkside | | > |
| Sat | 07 Feb 1953 | Leigh | 34 | Bramley | 10 | | Kirkhall | | > |
| Sat | 07 Feb 1953 | Liverpool C. | 3 | Swinton | 26 | | Knotty Ash | | > |
| Sat | 07 Feb 1953 | Orford Tannery | 2 | Warrington | 46 | | Wilderspool | | > |
| Sat | 07 Feb 1953 | St Helens | 20 | Oldham | 4 | | Knowsley | | > |
| Sat | 07 Feb 1953 | Salford | 24 | York | 14 | | The Willows | | > |
| Sat | 07 Feb 1953 | Wakefield T. | 9 | Leeds | 33 | | Belle Vue | | > |
| Sat | 07 Feb 1953 | Whitehaven | 13 | Hull | 6 | | Recreation Gnd | | > |
| Sat | 07 Feb 1953 | Widnes | 28 | NDLB | 0 | | Naughton | | > |
| Sat | 07 Feb 1953 | Wigan | 27 | Rochdale H. | 7 | | Central Park | | > |
| Sat | 14 Feb 1953 | Bramley | 3 | Leigh | 11 | | Barley Mow | | > |
| Sat | 14 Feb 1953 | Castleford | 2 | Huddersfield | 6 | | Wheldon Road | | > |
| Sat | 14 Feb 1953 | Doncaster | 5 | Hull KR | 5 | | Bentley Rd | | > |
| Sat | 14 Feb 1953 | Featherstone R. | 5 | Barrow | 15 | | Post Office Road | | > |
| Sat | 14 Feb 1953 | Hull | 14 | Whitehaven | 5 | | Boulevard | | > |
| Sat | 14 Feb 1953 | Keighley | 7 | Belle Vue R. | 0 | | Lawkholme Lane | | > |
| Sat | 14 Feb 1953 | NDLB | 3 | Widnes | 22 | | Craven Park | | > |
| Sat | 14 Feb 1953 | Oldham | 5 | St Helens | 5 | | Wigginton Rd | | > |
| Sat | 14 Feb 1953 | Swinton | 12 | Liverpool C. | 4 | | Station Road | | > |
| Sat | 14 Feb 1953 | Warrington | 46 | Orford Tannery | 8 | | Watersheddings | | > |
| Sat | 14 Feb 1953 | Workington | 12 | Hunslet | 8 | | Borough Park | | > |
| Tue | 17 Feb 1953 | Dewsbury | 2 | Halifax | 16 | | Crown Flatt | | > |
| Wed | 18 Feb 1953 | Leeds | 32 | Wakefield T. | 9 | | Wilderspool | | > |
| Wed | 18 Feb 1953 | York | 3 | Salford | 8 | | Headingley | | > |
| Thu | 19 Feb 1953 | Rochdale H. | 15 | Wigan | 24 | | Athletic Ground | | > |
| Mon | 23 Feb 1953 | Bradford N. | 17 | Batley | 3 | | Odsal | | > |
| Challenge Cup - Round 2
|
|---|
| Sat | 28 Feb 1953 | Bradford N. | 18 | Salford | 4 | | Odsal | | > |
| Sat | 28 Feb 1953 | Huddersfield | 21 | Barrow | 7 | | Fartown | | > |
| Sat | 28 Feb 1953 | Hull KR | 14 | Swinton | 3 | | Craven Park | | > |
| Sat | 28 Feb 1953 | Leeds | 26 | Widnes | 17 | | Headingley | | > |
| Sat | 28 Feb 1953 | Leigh | 7 | Halifax | 7 | | Kirkhall | | > |
| Sat | 28 Feb 1953 | St Helens | 28 | Belle Vue R. | 0 | | Knowsley | | > |
| Sat | 28 Feb 1953 | Warrington | 10 | Workington | 2 | | Wilderspool | | > |
| Sat | 28 Feb 1953 | Wigan | 18 | Hull | 10 | | Central Park | | > |
| Wed | 04 Mar 1953 | Halifax | 4 | Leigh | 7 | | Thrum | | > |
| Challenge Cup - Round 3
|
|---|
| Sat | 14 Mar 1953 | Bradford N. | 7 | Huddersfield | 17 | | Odsal | | > |
| Sat | 14 Mar 1953 | Leigh | 3 | St Helens | 12 | | Kirkhall | | > |
| Sat | 14 Mar 1953 | Warrington | 25 | Leeds | 8 | | Wilderspool | | > |
| Sat | 14 Mar 1953 | Wigan | 25 | Hull KR | 6 | | Central Park | | > |
| Challenge Cup - Semi Final
|
|---|
| Sat | 28 Mar 1953 | Huddersfield | 7 | Wigan | 0 | | Odsal | 58,722 | > |
| Sat | 28 Mar 1953 | Warrington | 3 | St Helens | 9 | | Station Road | 38,059 | > |
| Challenge Cup - Final
|
|---|
| Sat | 25 Apr 1953 | Huddersfield | 15 | St Helens | 10 | | Wembley | 89,588 | > |