Broughton Moor| 3 | | Mount Pleasant | | > | | Sat | 10 Feb 1951 | Belle Vue R. | 8 | Castleford | 5 | | Belle Vue | | > |
| Sat | 10 Feb 1951 | Bradford N. | 11 | St Helens | 6 | | Odsal | | > |
| Sat | 10 Feb 1951 | Featherstone R. | 9 | York | 5 | | Post Office Road | | > |
| Sat | 10 Feb 1951 | Halifax | 17 | Hunslet | 4 | | Thrum | | > |
| Sat | 10 Feb 1951 | Hull KR | 7 | Dewsbury | 13 | | Craven Park | | > |
| Sat | 10 Feb 1951 | Leeds | 23 | Oldham | 5 | | Headingley | | > |
| Sat | 10 Feb 1951 | Leigh | 43 | Latchford Albion | 0 | | Kirkhall | | > |
| Sat | 10 Feb 1951 | Liverpool S. | 5 | Workington | 25 | | Stanley | | > |
| Sat | 10 Feb 1951 | Llanelli | 9 | Barrow | 23 | | Llanelli | | > |
| Sat | 10 Feb 1951 | Rochdale H. | 0 | Wigan | 32 | | Athletic Ground | | > |
| Sat | 10 Feb 1951 | Salford | 16 | Wakefield T. | 10 | | The Willows | | > |
| Sat | 10 Feb 1951 | Swinton | 25 | Bramley | 4 | | Station Road | | > |
| Sat | 10 Feb 1951 | Warrington | 25 | Hull | 9 | | Wilderspool | | > |
| Sat | 10 Feb 1951 | Whitehaven | 2 | Huddersfield | 7 | | Recreation Gnd | | > |
| Sat | 10 Feb 1951 | Widnes | 8 | Keighley | 3 | | Naughton | | > |
| Sat | 17 Feb 1951 | Barrow | 39 | Llanelli | 5 | | Craven Park | | > |
| Sat | 17 Feb 1951 | Bramley | 7 | Swinton | 14 | | Barley Mow | | > |
| Sat | 17 Feb 1951 | Broughton Moor | 0 | Batley | 36 | | Recreation Gnd | | > |
| Sat | 17 Feb 1951 | Castleford | 2 | Belle Vue R. | 5 | | Wheldon Road | | > |
| Sat | 17 Feb 1951 | Dewsbury | 19 | Hull KR | 3 | | Crown Flatt | | > |
| Sat | 17 Feb 1951 | Huddersfield | 21 | Whitehaven | 9 | | Fartown | | > |
| Sat | 17 Feb 1951 | Hull | 3 | Warrington | 5 | | Boulevard | | > |
| Sat | 17 Feb 1951 | Hunslet | 2 | Halifax | 0 | | Parkside | | > |
| Sat | 17 Feb 1951 | Keighley | 6 | Widnes | 0 | | Lawkholme Lane | | > |
| Sat | 17 Feb 1951 | Latchford Albion | 0 | Leigh | 19 | | Wilderspool | | > |
| Sat | 17 Feb 1951 | Oldham | 13 | Leeds | 10 | | Watersheddings | | > |
| Sat | 17 Feb 1951 | St Helens | 4 | Bradford N. | 0 | | Knowsley | | > |
| Sat | 17 Feb 1951 | Wakefield T. | 2 | Salford | 6 | | Belle Vue | | > |
| Sat | 17 Feb 1951 | Wigan | 18 | Rochdale H. | 5 | | Central Park | | > |
| Sat | 17 Feb 1951 | Workington | 28 | Liverpool S. | 8 | | Borough Park | | > |
| Sat | 17 Feb 1951 | York | 5 | Featherstone R. | 4 | | Wigginton Rd | | > |
| Challenge Cup - Round 2
|
|---|
| Sat | 03 Mar 1951 | Barrow | 12 | Workington | 5 | | Craven Park | | > |
| Sat | 03 Mar 1951 | Belle Vue R. | 12 | Huddersfield | 14 | | Belle Vue | | > |
| Sat | 03 Mar 1951 | Bradford N. | 14 | Swinton | 4 | | Odsal | | > |
| Sat | 03 Mar 1951 | Keighley | 6 | Halifax | 7 | | Lawkholme Lane | | > |
| Sat | 03 Mar 1951 | Leeds | 20 | Leigh | 3 | | Headingley | | > |
| Sat | 03 Mar 1951 | Salford | 6 | Dewsbury | 0 | | The Willows | | > |
| Sat | 03 Mar 1951 | Warrington | 18 | Featherstone R. | 6 | | Wilderspool | | > |
| Sat | 03 Mar 1951 | Wigan | 16 | Batley | 8 | | Central Park | | > |
| Challenge Cup - Round 3
|
|---|
| Sat | 17 Mar 1951 | Barrow | 5 | Bradford N. | 4 | | Craven Park | | > |
| Sat | 17 Mar 1951 | Leeds | 15 | Halifax | 7 | | Headingley | | > |
| Sat | 17 Mar 1951 | Salford | 4 | Warrington | 8 | | The Willows | | > |
| Sat | 17 Mar 1951 | Wigan | 2 | Huddersfield | 0 | | Central Park | | > |
| Challenge Cup - Semi Final
|
|---|
| Sat | 07 Apr 1951 | Leeds | 14 | Barrow | 14 | | Odsal | 57,729 | > |
| Sat | 07 Apr 1951 | Wigan | 3 | Warrington | 2 | | Station Road | 44,621 | > |
| Wed | 11 Apr 1951 | Leeds | 13 | Barrow | 28 | | Fartown | 31,078 | > |
| Challenge Cup - Final
|
|---|
| Sat | 05 May 1951 | Wigan | 10 | Barrow | 0 | | Wembley | 94,262 | > |