Hull| 10 | | Craven Park | | > | | Sat | 04 Feb 1950 | Batley | 10 | Castleford | 9 | | Mount Pleasant | | > |
| Sat | 04 Feb 1950 | Belle Vue R. | 20 | Whitehaven | 2 | | Belle Vue | | > |
| Sat | 04 Feb 1950 | Broughton Moor | 5 | Wakefield T. | 28 | | Borough Park | | > |
| Sat | 04 Feb 1950 | Cardiff | 10 | Salford | 15 | | Penarth Road | | > |
| Sat | 04 Feb 1950 | Featherstone R. | 19 | Bramley | 2 | | Post Office Road | | > |
| Sat | 04 Feb 1950 | Huddersfield | 6 | Dewsbury | 9 | | Fartown | | > |
| Sat | 04 Feb 1950 | Hull KR | 2 | Warrington | 12 | | Craven Park | | > |
| Sat | 04 Feb 1950 | Leeds | 14 | Leigh | 7 | | Headingley | | > |
| Sat | 04 Feb 1950 | Oldham | 5 | Bradford N. | 16 | | Watersheddings | | > |
| Sat | 04 Feb 1950 | St Helens | 10 | Halifax | 6 | | Knowsley | | > |
| Sat | 04 Feb 1950 | Swinton | 24 | Liverpool S. | 10 | | Station Road | | > |
| Sat | 04 Feb 1950 | Widnes | 15 | Rochdale H. | 2 | | Naughton | | > |
| Sat | 04 Feb 1950 | Workington | 0 | Keighley | 5 | | Borough Park | | > |
| Sat | 04 Feb 1950 | Boys Club | 7 | Hunslet | 45 | | Central Park | | > |
| Sat | 04 Feb 1950 | York | 2 | Wigan | 38 | | Wigginton Rd | | > |
| Sat | 11 Feb 1950 | Bradford N. | 6 | Oldham | 8 | | Odsal | | > |
| Sat | 11 Feb 1950 | Bramley | 5 | Featherstone R. | 2 | | Barley Mow | | > |
| Sat | 11 Feb 1950 | Castleford | 6 | Batley | 6 | | Wheldon Road | | > |
| Sat | 11 Feb 1950 | Dewsbury | 4 | Huddersfield | 2 | | Crown Flatt | | > |
| Sat | 11 Feb 1950 | Halifax | 2 | St Helens | 0 | | Thrum | | > |
| Sat | 11 Feb 1950 | Hull | 0 | Barrow | 11 | | Boulevard | | > |
| Sat | 11 Feb 1950 | Hunslet | 18 | Boys Club | 9 | | Parkside | | > |
| Sat | 11 Feb 1950 | Keighley | 4 | Workington | 3 | | Lawkholme Lane | | > |
| Sat | 11 Feb 1950 | Leigh | 7 | Leeds | 2 | | Kirkhall | | > |
| Sat | 11 Feb 1950 | Liverpool S. | 9 | Swinton | 25 | | Stanley | | > |
| Sat | 11 Feb 1950 | Rochdale H. | 0 | Widnes | 27 | | Athletic Ground | | > |
| Sat | 11 Feb 1950 | Salford | 20 | Cardiff | 5 | | The Willows | | > |
| Sat | 11 Feb 1950 | Wakefield T. | 73 | Broughton Moor | 3 | | Belle Vue | | > |
| Sat | 11 Feb 1950 | Warrington | 24 | Hull KR | 4 | | Wilderspool | | > |
| Sat | 11 Feb 1950 | Whitehaven | 12 | Belle Vue R. | 0 | | Recreation Gnd | | > |
| Sat | 11 Feb 1950 | Wigan | 65 | York | 15 | | Central Park | | > |
| Challenge Cup - Round 2
|
|---|
| Sat | 25 Feb 1950 | Barrow | 6 | Featherstone R. | 2 | | Craven Park | | > |
| Sat | 25 Feb 1950 | Belle Vue R. | 6 | Hunslet | 17 | | Belle Vue | | > |
| Sat | 25 Feb 1950 | Leeds | 7 | Wigan | 2 | | Headingley | | > |
| Sat | 25 Feb 1950 | Salford | 2 | St Helens | 9 | | The Willows | | > |
| Sat | 25 Feb 1950 | Warrington | 17 | Swinton | 2 | | Wilderspool | | > |
| Thu | 02 Mar 1950 | Batley | 4 | Widnes | 12 | | Mount Pleasant | | > |
| Mon | 06 Mar 1950 | Bradford N. | 13 | Keighley | 2 | | Odsal | | > |
| Mon | 06 Mar 1950 | Wakefield T. | 2 | Dewsbury | 2 | | Belle Vue | | > |
| Wed | 08 Mar 1950 | Dewsbury | 10 | Wakefield T. | 15 | | Crown Flatt | | > |
| Challenge Cup - Round 3
|
|---|
| Sat | 11 Mar 1950 | Leeds | 14 | Wakefield T. | 8 | | Headingley | | > |
| Sat | 11 Mar 1950 | St Helens | 0 | Bradford N. | 0 | | Knowsley | | > |
| Sat | 11 Mar 1950 | Warrington | 21 | Hunslet | 7 | | Wilderspool | | > |
| Sat | 11 Mar 1950 | Widnes | 12 | Barrow | 7 | | Naughton | | > |
| Wed | 15 Mar 1950 | Bradford N. | 11 | St Helens | 0 | | Odsal | | > |
| Challenge Cup - Semi Final
|
|---|
| Sat | 01 Apr 1950 | Leeds | 4 | Warrington | 16 | | Odsal | 70,198 | > |
| Sat | 01 Apr 1950 | Widnes | 8 | Bradford N. | 0 | | Central Park | 24,783 | > |
| Challenge Cup - Final
|
|---|
| Sat | 06 May 1950 | Warrington | 19 | Widnes | 0 | | Wembley | 94,249 | > |