St Helens| 15 | | Cavendish Park | | > | | Sat | 26 Feb 1910 | Bramley | 3 | Rochdale H. | 3 | | Barley Mow | | > |
| Sat | 26 Feb 1910 | Dewsbury | 3 | Wakefield T. | 8 | | Crown Flatt | | > |
| Sat | 26 Feb 1910 | Hull KR | 3 | Leeds | 5 | | Craven Street | | > |
| Sat | 26 Feb 1910 | Hull | 10 | Leigh | 7 | | Boulevard | | > |
| Sat | 26 Feb 1910 | Keighley | 5 | Broughton R. | 0 | | Lawkholme Lane | | > |
| Sat | 26 Feb 1910 | Merthyr | 7 | Ebbw Vale | 12 | | College Field | | > |
| Sat | 26 Feb 1910 | Millom | 9 | Brookland | 4 | | Salthouse | | > |
| Sat | 26 Feb 1910 | Oldham | 0 | Huddersfield | 2 | | Watersheddings | | > |
| Sat | 26 Feb 1910 | Purston | 10 | Halifax | 23 | | [unknown] | | > |
| Sat | 26 Feb 1910 | Runcorn | 9 | Bradford N. | 4 | | Canal St | | > |
| Sat | 26 Feb 1910 | Salford | 64 | York Irish | 0 | | Weaste | | > |
| Sat | 26 Feb 1910 | Warrington | 31 | Wigan H. | 3 | | Wilderspool | | > |
| Sat | 26 Feb 1910 | Widnes | 0 | Hunslet | 6 | | Lowerhouse | | > |
| Sat | 26 Feb 1910 | Wigan | 16 | Swinton | 5 | | Central Park | | > |
| Sat | 26 Feb 1910 | York | 0 | Batley | 0 | | Wigginton Rd | | > |
| Tue | 01 Mar 1910 | Batley | 3 | York | 3 | | Mount Pleasant | | > |
| Tue | 01 Mar 1910 | Rochdale H. | 11 | Bramley | 5 | | Athletic Ground | | > |
| Thu | 03 Mar 1910 | York | 0 | Batley | 8 | | Boulevard | | > |
| Challenge Cup - Round 2
|
|---|
| Sat | 12 Mar 1910 | Batley | 0 | Hull | 8 | | Mount Pleasant | | > |
| Sat | 12 Mar 1910 | Halifax | 21 | St Helens | 6 | | Thrum | | > |
| Sat | 12 Mar 1910 | Huddersfield | 3 | Ebbw Vale | 8 | | Fartown | | > |
| Sat | 12 Mar 1910 | Hunslet | 2 | Wakefield T. | 2 | | Parkside | | > |
| Sat | 12 Mar 1910 | Leeds | 13 | Rochdale H. | 3 | | Headingley | | > |
| Sat | 12 Mar 1910 | Runcorn | 3 | Keighley | 5 | | Canal St | | > |
| Sat | 12 Mar 1910 | Salford | 12 | Wigan | 5 | | Weaste | | > |
| Sat | 12 Mar 1910 | Warrington | 37 | Millom | 0 | | Wilderspool | | > |
| Wed | 16 Mar 1910 | Wakefield T. | 2 | Hunslet | 5 | | Belle Vue | | > |
| Challenge Cup - Round 3
|
|---|
| Sat | 19 Mar 1910 | Hull | 13 | Halifax | 7 | | Boulevard | | > |
| Sat | 19 Mar 1910 | Keighley | 4 | Leeds | 7 | | Lawkholme Lane | | > |
| Sat | 19 Mar 1910 | Salford | 8 | Ebbw Vale | 2 | | Weaste | | > |
| Sat | 19 Mar 1910 | Warrington | 7 | Hunslet | 0 | | Wilderspool | | > |
| Challenge Cup - Semi Final
|
|---|
| Sat | 02 Apr 1910 | Hull | 20 | Salford | 6 | | Belle Vue | 11,000 | > |
| Sat | 02 Apr 1910 | Warrington | 10 | Leeds | 11 | | Wheater's | 14,959 | > |
| Challenge Cup - Final
|
|---|
| Sat | 16 Apr 1910 | Leeds | 7 | Hull | 7 | | Fartown | 19,413 | > |
| Challenge Cup - Final Replay
|
|---|
| Mon | 18 Apr 1910 | Leeds | 26 | Hull | 12 | | Fartown | 11,608 | > |